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Consolidated Standards of Reporting Trials (CONSORT) diagram of eligible patients. Abbreviations: mcfDNA, plasma microbial cell-free DNA; QC, quality control; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Journal: Open Forum Infectious Diseases

Article Title: Timing of Bronchoscopy and Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Host Pneumonia

doi: 10.1093/ofid/ofag361

Figure Lengend Snippet: Consolidated Standards of Reporting Trials (CONSORT) diagram of eligible patients. Abbreviations: mcfDNA, plasma microbial cell-free DNA; QC, quality control; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

Article Snippet: We evaluated the variability in diagnostic yield of usual care testing and plasma microbial cell-free DNA (mcfDNA) sequencing in the prospective observational Pneumonia in the Immunocompromised—Use of the Karius Test for the Detection of Undiagnosed Pathogens (PICKUP) study, specifically focusing on timing of testing relative to the onset of pneumonia.

Techniques: Clinical Proteomics, Control

Diagnostic yield of usual care (noninvasive diagnostic testing + bronchoscopy), bronchoscopy only, and plasma microbial cell-free DNA (mcfDNA) sequencing by enrollment site.

Journal: Open Forum Infectious Diseases

Article Title: Timing of Bronchoscopy and Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Host Pneumonia

doi: 10.1093/ofid/ofag361

Figure Lengend Snippet: Diagnostic yield of usual care (noninvasive diagnostic testing + bronchoscopy), bronchoscopy only, and plasma microbial cell-free DNA (mcfDNA) sequencing by enrollment site.

Article Snippet: We evaluated the variability in diagnostic yield of usual care testing and plasma microbial cell-free DNA (mcfDNA) sequencing in the prospective observational Pneumonia in the Immunocompromised—Use of the Karius Test for the Detection of Undiagnosed Pathogens (PICKUP) study, specifically focusing on timing of testing relative to the onset of pneumonia.

Techniques: Diagnostic Assay, Clinical Proteomics, Sequencing

Diagnostic yield of bronchoscopy, plasma mcfDNA sequencing, and additive diagnostic value (ADV) of plasma microbial cell-free DNA (mcfDNA) by time from first abnormal imaging to bronchoscopy and plasma specimen collection.

Journal: Open Forum Infectious Diseases

Article Title: Timing of Bronchoscopy and Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Host Pneumonia

doi: 10.1093/ofid/ofag361

Figure Lengend Snippet: Diagnostic yield of bronchoscopy, plasma mcfDNA sequencing, and additive diagnostic value (ADV) of plasma microbial cell-free DNA (mcfDNA) by time from first abnormal imaging to bronchoscopy and plasma specimen collection.

Article Snippet: We evaluated the variability in diagnostic yield of usual care testing and plasma microbial cell-free DNA (mcfDNA) sequencing in the prospective observational Pneumonia in the Immunocompromised—Use of the Karius Test for the Detection of Undiagnosed Pathogens (PICKUP) study, specifically focusing on timing of testing relative to the onset of pneumonia.

Techniques: Diagnostic Assay, Clinical Proteomics, Sequencing, Imaging

Proposed diagnostic approach to timing of bronchoscopy and plasma mcfDNA sequencing in immunocompromised patients with suspected pneumonia. Abbreviations: BAL, bronchoalveolar lavage; CT, computed tomography; CXR, chest X-ray; mcfDNA, plasma microbial cell-free DNA.

Journal: Open Forum Infectious Diseases

Article Title: Timing of Bronchoscopy and Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Host Pneumonia

doi: 10.1093/ofid/ofag361

Figure Lengend Snippet: Proposed diagnostic approach to timing of bronchoscopy and plasma mcfDNA sequencing in immunocompromised patients with suspected pneumonia. Abbreviations: BAL, bronchoalveolar lavage; CT, computed tomography; CXR, chest X-ray; mcfDNA, plasma microbial cell-free DNA.

Article Snippet: We evaluated the variability in diagnostic yield of usual care testing and plasma microbial cell-free DNA (mcfDNA) sequencing in the prospective observational Pneumonia in the Immunocompromised—Use of the Karius Test for the Detection of Undiagnosed Pathogens (PICKUP) study, specifically focusing on timing of testing relative to the onset of pneumonia.

Techniques: Diagnostic Assay, Clinical Proteomics, Sequencing, Computed Tomography